Time delay evaluation on thewater-leaving irradiance retrieved from empirical models and satellite imagery

Temporal delays and spatial randomness between ground-based data and satellite overpass involve important deviations between the empirical model output and real data; these are factors poorly considered in the model calibration. The inorganic matter-generated turbidity in Lake Chapala (Mexico) was taken as a study case to expose the influence of such factors. Ground-based data from this study and historical records were used as references. We take advantage of the at-surface reflectance from Landsat-8, sun-glint corrections, a reduced NIR-band range, and null organic matter incidence in these wavelengths to diminish the physical phenomena-related radiometric artifacts; leaving the spatio-temporal relationships as the principal factor inducing the model uncertainty. Non-linear correlations were assessed to calibrate the best empirical model; none of them presented a strong relationship (<73%), including that based on hourly delays. This last model had the best predictability only for the summer-fall season, explaining 71% of the turbidity variation in 2016, and 59% in 2017, with RMSEs < 24%. The instantaneous turbidity maps depicted the hydrodynamic complexity of the lake, highlighting a strong component of spatial randomness associated with the temporal delays. Reasonably, robust empirical models will be developed if several dates and sampling-sites are synchronized with more satellite overpasses.</p

Synthesis and screening of 6‐alkoxy purine analogs as cell type‐selective apoptotic inducers in Jurkat cells

Ministerio de Ciencia e Innovacion, Grant/Award Number: RTC-2017-6620; Ministerio de Educacion, Cultura y Deporte, Grant/Award Number: FPU 14/00818Purines are ubiquitous structures in cell biology involved in a multitude of cellular processes, because of which substituted purines and analogs are considered excellent scaffolds in drug design. In this study, we explored the key structural features of a purine‐based proapoptotic hit, 8‐tert‐butyl‐9‐phenyl‐6‐benzyloxy‐9Hpurine (1), by setting up a library of 6‐alkoxy purines with the aim of elucidating the structural requirements that govern its biological activity and to study the cell selectivity of this chemotype. This was done by a phenotypic screening approach based on cell cycle analysis of a panel of six human cancer cell lines, including T cell leukemia Jurkat cells. From this study, two derivatives (12 and 13) were identified as Jurkat‐selective proapoptotic compounds, displaying superior potency and cell selectivity than hit 1.Instituto de Salud Carlos III Spanish Government European Commission RTC-2017-6620Ministerio de Educacion, Cultura y Deporte FPU 14/0081

An Activin Receptor IA/Activin-Like Kinase-2 (R206H) Mutation in Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is an exceptionally rare genetic disease that is characterised by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomical areas.This disease is caused by a mutation in activin receptor IA/activin-like kinase-2 (ACVR1/ALK2). A Mexican family with one member affected by FOP was studied. The patient is a 19-year-old female who first presented with symptoms of FOP at 8 years old; she developed spontaneous and painful swelling of the right scapular area accompanied by functional limitation of movement. Mutation analysis was performed in which genomic DNA as PCR amplified using primers flanking exons 4 and 6, and PCR products were digested with Cac8I and HphI restriction enzymes.The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G>A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS) domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP) signalling that causes FO

Correlation Analysis of People Attitude and the Development of Chemical Processes in the Human Body

This chemical science investigation was made to efficiently understand the way in which ionic substances operate in the human body and its correlation that they can have with the attitude of people, whose evaluation was carried out according to the analysis of three actions developed in the human body, such as digestion factors, family, work and social relationships (emotional actions) and the health of 10 people surveyed in the city of Tijuana, Baja California. This evaluation had a main hypothesis at the beginning of the investigation, indicating that, of the three factors mentioned, the one that links emotions had the greatest effect on the behavior of the people evaluated, with the aspect of family and work relationships being of primary importance; followed by the health factor and finally the digestion factor. This scientific study included an analysis of three principal aspects, being first the daily food as a nutrition action, followed a chemical analysis of ionic substances of the human body of the 10 persons evaluated. In addition, the third aspect evaluated was the emotional state of the people and a clinic with the urine analysis were considered to indicate the pH, temperature and oxygen level of each person, with which the main chemical elements of the ionic substances that can circulate through the human body were obtained, as part of the food intake. and drinks, emotional factor and digestion. This scientific study was made from March to May of 2023

Apoptosis in chronic cutaneous lupus erythematosus, discoid lupus, and lupus profundus

: Introduction: Lupus erythematosus is a multisystemic disease that is characterized by autoantibody production and immune complex deposition in such tissues as the mucosa, joints, the central nervous system, and skin. Cutaneous lupus erythematosus is categorized as acute, subacute, and chronic. Chronic cutaneous lupus erythematosus comprises discoid lupus erythematosus (DLE) and lupus profundus (LP). Aim: To analyze the expression of proapoptotic molecules in patients with lupus erythematosus discoid and lupus profundus. Material and methods: Descriptive study, the study groups comprised 10 cases of LP and 10 cases of DLE, and a control. Skin samples of cases and controls were processed for immunohistochemistry and by TUNEL technique. The database and statistical analysis was performed (statistical test X2) SPSS (Chicago, IL, USA). Results: Apoptotic features were broadly distributed along the skin biopsies in epidermal keratinocytes as well as at dermis. By immunohistochemistry the expression of Fas receptor and Fas-L was higher in the skin of lupus patients compared with controls. We also noted differences in Fas-L, -Fas, and -Bax proteins expression intensity in discoid lupus erythematosus patients in the epidermis, and hair follicles. Conclusions: Fas and Fas-L are expressed similarly in LP and DLE

The use of interactive response systems as a tool to favor proactive learning in Engineering

El desarrollo de las tecnologías de la información y la comunicación (TIC) ha permitido el surgimiento de herramientas didácticas en el campo de la educación, proporcionando herramientas prácticas para apoyar a las clases presenciales. En este contexto, los sistemas electrónicos de respuesta estudiantil pueden ser útiles para introducir un elemento tecnológico motivador en las lecciones, así como una nueva metodología. En este estudio, además del uso de los sistemas de respuesta interactiva o clickers, se ha introducido la tecnología de aprendizaje móvil mediante la elaboración de una metodología de uso de las herramientas Kahoot y Telegram en la asignatura "Fundamentos Físicos en la Ingeniería II" del Grado en Ingeniería Electrónica Industrial. El Departamento de Física Aplicada de la Universidad de Córdoba tiene una amplia experiencia en el uso de Clickers en clases teóricas con grupos grandes para diferentes grados universitarios, pero ahora el uso de tecnologías móviles de aprendizaje se ha introducido en grupos de tamaño medio para clases prácticas. Usando esta nueva metodología, los estudiantes de grupos medianos realizan un cuestionario durante la lección de resolución de problemas, donde utilizaron sus conocimientos adquiridos durante la clase. La realización del cuestionario permite a los profesores evaluar en tiempo real el nivel del estudiante y utilizar la retroalimentación para abordar los problemas iniciales y los malentendidos. Los resultados muestran que los sistemas de respuesta interactiva son altamente valorados por los estudiantes, que lo perciben como una herramienta para mejorar el aprendizaje y aumentar la competencia en el aula.The development of information and communication technologies (ICT) has enabled the emergence of teaching tools in the education field, providing practical tools to support face-to-face classes. In this context, electronic student response systems can be useful for introducing a motivating technological element into the lessons, as well as a new methodology. In this study, in addition to the use of interactive response systems or clickers, mobile learning technology has been introduced by developing a methodology for using the Kahoot and Telegram tools in the subject “Physical Foundations of Engineering II” of Electronic Engineering Degree. Department of Applied Physics of University of Cordoba has a broad experience using Clickers in theory classes with large groups for different university degrees, but now the use of mobile learning technologies has been introduced in medium-sized groups for practical classes. Using this new methodology, students of medium-sized groups perform a quiz during the problem solving lesson, where they utilized their knowledge gained during the class. The completion of the quiz allows teachers to assess the student’s level in real time, and to use the feedback to address initial problems and misunderstandings. Results show the interactive response systems are highly valued by students, who perceive it as a tool to improve learning and increase competition in the classroom

Opportunistic detection of atrial fibrillation in subjects aged 65 years or older in primare care: a randomised clinical trial of efficacy. DOFA-AP study protocol.

Clinical Practice Guidelines recommend using peripheral blood pulse measuring as a screening test for Atrial Fibrillation. However, there is no adequate evidence supporting the efficacy of such procedure in primary care clinical practice. This paper describes a study protocol designed to verify whether early opportunistic screening for Atrial Fibrillation by measuring blood pulse is more effective than regular practice in subjects aged 65 years attending primary care centers.post-print290 K

Generación de escenarios regionalizados de cambio climático para España

El presente informe resume la primera fase del proyecto del Instituto Nacional de Meteorología (INM), actualmente Agencia Estatal de Meteorología (AEMet), de generación de proyecciones regionalizadas de cambio climático para suministrar a los diferentes sectores sensibles a las condiciones climáticas. En esta fase primó la urgencia de proporcionar unas primeras estimaciones de la evolución del clima en el siglo XXI con resoluciones temporales y espaciales que pudieran ser útiles para los diferentes modelos de impacto. Esta necesidad motivó que se utilizasen tanto las bases de datos ya disponibles como los métodos suficientemente probados en otros contextos y que no se abordasen largos desarrollos que pudiesen retrasar la disponibilidad de este primer suministro de datos de proyecciones regionalizadas. Este informe tiene el carácter de documento de acompañamiento de los datos, en el que además de explicar los métodos de generación de los datos, se explican sus limitaciones en un contexto lo más amplio posible. Dentro de estas explicaciones se han incluido secciones dedicadas a describir las incertidumbres del proceso de generación de proyecciones climáticas y secciones dedicadas a discutir cuestiones metodológicas. Esta es la primera entrega de un proceso continuo de revisión periódica de las proyecciones regionales con los mejores datos procedentes de modelos globales, las mejores observaciones y las mejores técnicas de regionalización. La segunda fase del proyecto busca involucrar a la mayor parte de la comunidad científica española activa en este campo. En esta segunda fase ya no es tan prioritaria la inmediatez de los resultados como el desarrollo de nuevos métodos y la apuesta decidida por una investigación de calidad que respalde las proyecciones climáticas futuras con una mayor comprensión de las condiciones climáticas presentes y pasadas